CATTLEMASTER GOLD FP 5

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Description

IBR, BVD Types I and II, PI3 and BRSV. Give 2 ml SQ. Repeat in 3 weeks. When used for fetal protection,
give at 5 and 2 weeks prior to breeding. Calves vaccinated before 6 months of age should be
revaccinated at 6 months of age. Annual booster is recommended. Modified live and killed product,
requires mixing. Safe for pregnant cows.

CattleMaster GOLD FP 5

Zoetis
Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 -Respiratory Syncytial Virus Vaccine
Modified Live and Killed Virus
PRODUCT DESCRIPTION: CattleMaster GOLD FP 5 is for vaccination of healthy cattle, including pregnant cows, as
an aid in preventing abortion caused by infectious bovine rhinotracheitis (IBR, bovine herpesvirus Type 1),
persistently infected calves caused by bovine virus diarrhea (BVD) virus Types 1 and 2, and respiratory disease
caused by IBR, BVD (Types 1 and 2), parainfluenza 3 (PI 3 ), and bovine respiratory syncytial virus (BRSV).
CattleMaster GOLD FP 5 is a freeze-dried preparation of chemically altered strains of IBR and PI 3 viruses and
modified live BRSV, plus a liquid, adjuvanted preparation of inactivated BVD virus (Types 1and 2). The liquid
component is used to rehydrate the freeze-dried component. Viral antigens are propagated on an established cell
line. This product contains a unique combination of adjuvants, including Amphigen , to enhance the immune
response to its fractions. The BVD diluent of CattleMaster GOLD FP 5 is further processed by a proprietary system to
help assure consistency of the formulation.
DISEASE DESCRIPTION: IBR and BVD are commonly associated with reproductive and respiratory disease while
BRSV and PI 3 are predominantly associated with respiratory disease. IBR virus infection is characterized by high
temperature, excessive nasal discharge, conjunctivitis and ocular discharge, inflamed nose (red nose), increased
rate of respiration, coughing, loss of appetite, and depression. Cattle infected during pregnancy may abort. A
characteristic of IBR virus is that it establishes a latent infection in sensory neurons, typically trigeminal ganglia or
iliosacral dorsal root ganglia. 1 From these sites of latency, it can be reactivated when an infected animal is stressed or
injured. Subsequently, the virus is shed and transmitted by contact to other cattle.
BVD virus may be transmitted in nasal secretions, saliva, blood, feces, and/or urine, and by direct contact with
contaminated objects; it invades through the nose and mouth and replicates systemically. Infection during pregnancy
may result in abortion, fetal resorption, or congenital malformation of the fetus. Moreover, if susceptible cows are
infected with noncytopathic BVD virus during the first trimester of pregnancy, their calves may be born persistently
infected with the virus. Exposure of those calves to certain virulent BVD virus strains may precipitate BVD-mucosal
disease. Both BVD Types 1 and 2 can show a variety of clinical signs. The signs may be mild and not readily
apparent. Clinical signs may include severe immune suppression, diarrhea, anorexia, depression, fever and
respiratory disease. If infected with some Type 2 strains of BVD, severe thrombocytopenia may occur and
hemorrhaging may be seen.
PI 3 virus usually localizes in the upper respiratory tract, causing elevated temperature and moderate nasal and ocular
discharge. Although clinical signs typically are mild, PI 3 infection weakens respiratory tissues. Invasion and replication
of other pathogens, particularly Pasteurella spp., is thereby facilitated and may result in pneumonia.
BRSV is the etiologic agent of a specific viral respiratory disease of cattle of all ages, including nursing calves.
Infection is characterized by rapid breathing, coughing, loss of appetite, discharge from the nose and eyes, fever, and
swelling around the throat and neck. In an acute outbreak, deaths may follow within 48 hours after onset of signs.
Clinically, BRSV infection may be indistinguishable from other viral infections associated with the bovine respiratory
disease complex. BRSV infection, like PI 3 , facilitates invasion and replication of other respiratory pathogens.
Exacerbation of clinical signs has been documented when concurrent BRSV and BVD or IBR infection exists.

SAFETY AND EFFICACY: In safety studies conducted with CattleMaster GOLD FP 5, no significant adverse
reactions to vaccination were observed and vaccinated pregnant cattle delivered normal, healthy calves. Safety was
demonstrated in prebreeding and pregnant cows in all 3 trimesters. Transient local swellings, attributable to the
adjuvant formulation, were occasionally observed at the injection sites.
The latency and subsequent excretion of the IBR virus fraction of CattleMaster GOLD FP 5 was determined in a
safety study in which cattle were vaccinated intramuscularly with the attenuated, temperature-sensitive IBR virus
component and subsequently given corticosteroid to reactivate latent herpesvirus. Vaccination resulted in a
characteristic serological response that remained unaltered even after corticosteroid treatment, indicating a lack of
viral reactivation. Also, no BHV1 was recovered from mucosal swabs collected postvaccination or postcorticosteroid
treatment, nor was it transmitted to nonvaccinated sentinel calves commingled with the vaccinates for the duration of
the study. Further, no BHV1 DNA or latency-related RNA was detected in trigeminal or iliosacral spinal dorsal root
ganglia collected after the administration of corticosteroid. Both nucleic acids were detected in a single cervical
ganglion sample, suggesting a direct or proximate intraneural injection. BHV1 given by intramuscular (IM) injection
could not be reactivated from trigeminal ganglia, the primary site of BHV1 latency, demonstrating a lack of efficient
viral replication in those sensory neurons. Excluding possible injection into nervous tissue (from which reactivation
was not observed), the IBR fraction of CattleMaster GOLD FP 5 given by the IM route showed no propensity to
establish latent herpesvirus infections.
Efficacy of each fraction of CattleMaster GOLD FP 5 was demonstrated in challenge-of-immunity studies. Cattle
vaccinated with any fraction of CattleMaster GOLD FP 5, followed by intranasal challenge with a disease-causing
strain of that fraction, had significantly fewer clinical signs than nonvaccinated control cattle.
Efficacy of the IBR and BVD Types 1 and 2 fractions of CattleMaster GOLD FP 5 were additionally demonstrated in
challenge-of-immunity, fetal protection studies. The effectiveness of CattleMaster GOLD FP 5 in preventing IBR-
induced abortion was demonstrated by vaccinating susceptible heifers approximately 5 and 2 weeks prior to
breeding. The vaccinated heifers, along with a group of nonvaccinated controls, were challenged with virulent IBR
virus (Cooper strain) at approximately 180 days postbreeding. Following challenge, >90% of vaccinated cows gave
birth to healthy calves whereas >90% of the nonvaccinated controls aborted.
A similar study design was used to demonstrate the effectiveness of CattleMaster GOLD FP 5in preventing
persistently infected calves with both BVD Types 1 and 2. In these studies, cows were challenged at approximately
82 days postbreeding using virulent strains of BVD. In nonvaccinated controls, challenge with BVD Type 1 resulted in
100% fetal infection, and challenge with BVD Type 2 resulted in greater than 85% fetal infection. Conversely, 100%
of calves born to cows vaccinated with CattleMaster GOLD FP 5 were protected from persistent infection following
challenge by both BVD Types 1 and 2.
DIRECTIONS:
1. General Directions: Vaccination of healthy cattle, including pregnant cows, is recommended. Aseptically rehydrate
the freeze-dried vaccine with the liquid vaccine provided, shake well, and administer 2 mL subcutaneously.
2. Primary Vaccination: Healthy cattle should receive an initial 2 doses 3 weeks apart. As an aid in preventing IBR-
induced abortion and BVD persistently infected calves, administer a 2-mL dose at approximately 5 and 2 weeks prior
to breeding. Calves vaccinated before the age of 6 months should be revaccinated after 6 months of age.
3. Revaccination: Annual revaccination with a single dose is recommended.

4. Good animal husbandry and herd health management practices should be employed.
PRECAUTIONS:
1. Store at 2-7C. Prolonged exposure to higher temperatures and/or direct sunlight may adversely affect potency.
Do not freeze.
2. Use entire contents when first opened.
3. Sterilized syringes and needles should be used to administer this vaccine. Do not sterilize with chemicals because
traces of disinfectant may inactivate the vaccine.
4. Transient local reactions may be observed at the injection site.
5. Burn containers and all unused contents.
6. Do not vaccinate within 21 days before slaughter.
7. Contains gentamicin as preservative.
8. Routine handling of lactating dairy cattle, including administration of vaccines such as CattleMaster GOLD FP 5,
has been associated with transient reduction of milk production.
9. As with many vaccines, anaphylaxis may occur after use. Initial antidote of epinephrine is recommended and
should be followed with appropriate supportive therapy.
10. This product has been shown to be efficacious in healthy animals. A protective immune response may not be
elicited if animals are persistently infected with BVD virus or incubating an infectious disease, are malnourished or
parasitized, are stressed due to shipment or environmental conditions, are otherwise immunocompromised, or the
vaccine is not administered in accordance with label directions.
REFERENCES:
1. Jones C: Alphaherpesvirus latency: Its role in disease and survival of the virus in nature. Adv in Vir Res 51:81-133,
1999.
Technical inquiries should be directed to Zoetis Inc. Veterinary Services, (888) 963-8471 (USA), (800) 461-0917
(Canada).
For veterinary use only
U.S. Veterinary License No. 190
Zoetis Inc., Kalamazoo, MI 49007, USA
30063800
Presentation: 5 dose, 10 dose and 25 dose vials.
CPN: 3690218.4

Additional information

Weight N/A
Doses

10 Doses, 25 Doses

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