Titanium 5 L5 HB contains BVD Type I and BVD Type II and is recommended for the vaccination of healthy cows and heifers, no less than 30 days prior to breeding, as an aid in the prevention of disease caused by infectious bovine rhinotracheitis virus (IBR), bovine virus diarrhea virus, Type I (BVD), bovine virus diarrhea virus, Type II (BVD), bovine parainfluenza3 virus (PI3), bovine respiratory syncytial virus (BRSV) and Leptospira borgpetersenii serovar and Leptospira canicola-grippotyphosa-hardjo-icterohaemorrhagiae-pomona. Titanium 5 L5 HB may be administered to pregnant cattle provided they were vaccinated, according to label directions, with Titanium 3, Titanium 4 L5, Titanium 5 or Titanium 5 L5 HB 30 to 60 days prior to breeding. Inject 2 mL subcutaneously using aseptic technique, followed by a second dose of monovalent bovine respiratory syncytial virus vaccine (Titanium BRSV) to be given 14 to 28 days after the first dose. Annual revaccination is recommended. Calves vaccinated before weaning should be revaccinated 30 days after weaning when the possible influence of maternal antibodies is decreased.